Association analysis of 9,560 prostate cancer cases from the International Consortium of Prostate Cancer Genetics confirms the role of reported prostate-cancer associated SNPs for familial disease
Identifieur interne : 004825 ( Main/Exploration ); précédent : 004824; suivant : 004826Association analysis of 9,560 prostate cancer cases from the International Consortium of Prostate Cancer Genetics confirms the role of reported prostate-cancer associated SNPs for familial disease
Auteurs : Craig C. Teerlink ; Stephen N. Thibodeau [États-Unis] ; Shannon K. Mcdonnell [États-Unis] ; Daniel J. Schaid [États-Unis] ; Antje Rinckleb [Allemagne] ; Christiane Maier [Allemagne] ; Walther Vogel [Allemagne] ; Geraldine Cancel-Tassin [France] ; Christophe Egrot [France] ; Olivier Cussenot [France] ; William D. Foulkes [Canada] ; Graham G. Giles [Australie] ; John L. Hopper [Australie] ; Gianluca Severi [Australie] ; Ros Eeles [Royaume-Uni] ; Douglas Easton [Royaume-Uni] ; Zsofia Kote-Jarai [Royaume-Uni] ; Michelle Guy [Royaume-Uni] ; Kathleen A. Cooney [États-Unis] ; Anna M. Ray [États-Unis] ; Kimberly A. Zuhlke [États-Unis] ; Ethan M. Lange [États-Unis] ; Liesel M. Fitzgerald [États-Unis] ; Janet L. Stanford [États-Unis] ; Elaine A. Ostrander [États-Unis] ; Kathleen E. Wiley [États-Unis] ; Sarah D. Isaacs [États-Unis] ; Patrick C. Walsh [États-Unis] ; William B. Isaacs [États-Unis] ; Tiina Wahlfors [Finlande] ; Teuvo Tammela [Finlande] ; Johanna Schleutker [Finlande] ; Fredrik Wiklund [Suède] ; Henrik Grönberg [Suède] ; Monica Emanuelsson [Suède] ; John Carpten [États-Unis] ; Joan Bailey-Wilson [États-Unis] ; Alice S. Whittemore [États-Unis] ; Ingrid Oakley-Girvan [États-Unis] ; Chih-Lin Hsieh [États-Unis] ; William J. Catalona [États-Unis] ; S. Lilly Zheng [États-Unis] ; Guangfu Jin [États-Unis] ; Lingyi Lu [États-Unis] ; Jianfeng Xu [États-Unis] ; Nicola J. Camp ; Lisa A. Cannon-Albright [États-Unis]Source :
- Human genetics [ 0340-6717 ] ; 2013.
Abstract
Previous GWAS studies have reported significant associations between various common SNPs and prostate cancer risk using cases unselected for family history. How these variants influence risk in familial prostate cancer is not well studied. Here, we analyzed 25 previously reported SNPs across 14 loci from prior prostate cancer GWAS. The International Consortium for Prostate Cancer Genetics (ICPCG) previously validated some of these using a family-based association method (FBAT). However, this approach suffered reduced power due to the conditional statistics implemented in FBAT. Here, we use a case-control design with an empirical analysis strategy to analyze the ICPCG resource for association between these 25 SNPs and familial prostate cancer risk. Fourteen sites contributed 12,506 samples (9,560 prostate cancer cases, 3,368 with aggressive disease, and 2,946 controls from 2,283 pedigrees). We performed association analysis with Genie software which accounts for relationships. We analyzed all familial prostate cancer cases and the subset of aggressive cases. For the familial prostate cancer phenotype, 20 of the 25 SNPs were at least nominally associated with prostate cancer and 16 remained significant after multiple testing correction (p≤1E−3) occurring on chromosomal bands 6q25, 7p15, 8q24, 10q11, 11q13, 17q12, 17q24, and Xp11. For aggressive disease, 16 of the SNPs had at least nominal evidence and 8 were statistically significant including 2p15. The results indicate that the majority of common, low-risk alleles identified in GWAS studies for all prostate cancer also contribute risk for familial prostate cancer, and that some may be contribute risk to aggressive disease.
Url:
DOI: 10.1007/s00439-013-1384-2
PubMed: 24162621
PubMed Central: 3945961
Affiliations:
- Allemagne, Australie, Canada, Finlande, France, Royaume-Uni, Suède, États-Unis
- Arizona, Bade-Wurtemberg, Californie, Caroline du Nord, District de Tübingen, Finlande occidentale, Illinois, Maryland, Michigan, Minnesota, Québec, Svealand, Utah, Victoria (État), Washington (État), Île-de-France
- Melbourne, Montréal, Stockholm, Turku, Ulm
- Université McGill, Université d'Ulm, Université de Melbourne, Université de Turku
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Cooney</name><affiliation><nlm:aff id="A16">University of Michigan ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A17">Departments of Internal Medicine and Urology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Departments of Internal Medicine and Urology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Ray, Anna M" sort="Ray, Anna M" uniqKey="Ray A" first="Anna M." last="Ray">Anna M. Ray</name><affiliation><nlm:aff id="A16">University of Michigan ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A17">Departments of Internal Medicine and Urology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Departments of Internal Medicine and Urology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Zuhlke, Kimberly A" sort="Zuhlke, Kimberly A" uniqKey="Zuhlke K" first="Kimberly A." last="Zuhlke">Kimberly A. Zuhlke</name><affiliation><nlm:aff id="A16">University of Michigan ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A17">Departments of Internal Medicine and Urology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Departments of Internal Medicine and Urology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Lange, Ethan M" sort="Lange, Ethan M" uniqKey="Lange E" first="Ethan M." last="Lange">Ethan M. Lange</name><affiliation><nlm:aff id="A16">University of Michigan ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A18">Departments of Genetics and Biostatistics, University of North Carolina, Chapel Hill, NC 27599</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Departments of Genetics and Biostatistics, University of North Carolina, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M." last="Fitzgerald">Liesel M. Fitzgerald</name><affiliation><nlm:aff id="A19">FHCRC/NHGRI ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A20">Fred Hutchinson Cancer Research Center (FHCRC), Division of Public Health Sciences, Seattle, WA 98195</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center (FHCRC), Division of Public Health Sciences, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Stanford, Janet L" sort="Stanford, Janet L" uniqKey="Stanford J" first="Janet L." last="Stanford">Janet L. Stanford</name><affiliation><nlm:aff id="A19">FHCRC/NHGRI ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A20">Fred Hutchinson Cancer Research Center (FHCRC), Division of Public Health Sciences, Seattle, WA 98195</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center (FHCRC), Division of Public Health Sciences, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Ostrander, Elaine A" sort="Ostrander, Elaine A" uniqKey="Ostrander E" first="Elaine A." last="Ostrander">Elaine A. Ostrander</name><affiliation><nlm:aff id="A19">FHCRC/NHGRI ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A21">Cancer Genetics Branch, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Cancer Genetics Branch, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Wiley, Kathleen E" sort="Wiley, Kathleen E" uniqKey="Wiley K" first="Kathleen E." last="Wiley">Kathleen E. Wiley</name><affiliation wicri:level="2"><nlm:aff id="A22">Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD 21287</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Isaacs, Sarah D" sort="Isaacs, Sarah D" uniqKey="Isaacs S" first="Sarah D." last="Isaacs">Sarah D. Isaacs</name><affiliation wicri:level="2"><nlm:aff id="A22">Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD 21287</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Walsh, Patrick C" sort="Walsh, Patrick C" uniqKey="Walsh P" first="Patrick C." last="Walsh">Patrick C. Walsh</name><affiliation wicri:level="2"><nlm:aff id="A22">Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD 21287</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B." last="Isaacs">William B. Isaacs</name><affiliation wicri:level="2"><nlm:aff id="A22">Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD 21287</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Wahlfors, Tiina" sort="Wahlfors, Tiina" uniqKey="Wahlfors T" first="Tiina" last="Wahlfors">Tiina Wahlfors</name><affiliation><nlm:aff id="A23">University of Tampere ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Institute of Biomedical Technology, University of Tampere, BioMediTech, and Centre for Laboratory Medicine, Tampere University Hospital, Tampere 33520, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Biomedical Technology, University of Tampere, BioMediTech, and Centre for Laboratory Medicine, Tampere University Hospital, Tampere 33520</wicri:regionArea><wicri:noRegion>Tampere 33520</wicri:noRegion></affiliation></author><author><name sortKey="Tammela, Teuvo" sort="Tammela, Teuvo" uniqKey="Tammela T" first="Teuvo" last="Tammela">Teuvo Tammela</name><affiliation><nlm:aff id="A23">University of Tampere ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="A25">Department of Urology, University of Tampere and Tampere University Hospital, Tampere 33520, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Urology, University of Tampere and Tampere University Hospital, Tampere 33520</wicri:regionArea><wicri:noRegion>Tampere 33520</wicri:noRegion></affiliation></author><author><name sortKey="Schleutker, Johanna" sort="Schleutker, Johanna" uniqKey="Schleutker J" first="Johanna" last="Schleutker">Johanna Schleutker</name><affiliation><nlm:aff id="A23">University of Tampere ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="4"><nlm:aff id="A26">Department of Medical Biochemistry and Genetics, University of Turku, Turku 20520, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medical Biochemistry and Genetics, University of Turku, Turku 20520</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region><settlement type="city">Turku</settlement></placeName><orgName type="university">Université de Turku</orgName></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation><nlm:aff id="A27">University of Umeå ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="3"><nlm:aff id="A28">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name><affiliation><nlm:aff id="A27">University of Umeå ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="3"><nlm:aff id="A28">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Emanuelsson, Monica" sort="Emanuelsson, Monica" uniqKey="Emanuelsson M" first="Monica" last="Emanuelsson">Monica Emanuelsson</name><affiliation><nlm:aff id="A27">University of Umeå ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="A29">Oncologic Centre, Umeå University, Umeå 90187, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Oncologic Centre, Umeå University, Umeå 90187</wicri:regionArea><wicri:noRegion>Umeå 90187</wicri:noRegion></affiliation></author><author><name sortKey="Carpten, John" sort="Carpten, John" uniqKey="Carpten J" first="John" last="Carpten">John Carpten</name><affiliation wicri:level="2"><nlm:aff id="A30">Integrated Cancer Genomics Division, TGen, Phoenix, AZ 85004</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Integrated Cancer Genomics Division, TGen, Phoenix</wicri:cityArea></affiliation></author><author><name sortKey="Bailey Wilson, Joan" sort="Bailey Wilson, Joan" uniqKey="Bailey Wilson J" first="Joan" last="Bailey-Wilson">Joan Bailey-Wilson</name><affiliation wicri:level="2"><nlm:aff id="A31">Inherited Disease Research Branch, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Inherited Disease Research Branch, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name><affiliation><nlm:aff id="A32">Stanford University ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A33">Department of Health Research and Policy, Stanford School of Medicine, Stanford, CA 94305</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Health Research and Policy, Stanford School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Oakley Girvan, Ingrid" sort="Oakley Girvan, Ingrid" uniqKey="Oakley Girvan I" first="Ingrid" last="Oakley-Girvan">Ingrid Oakley-Girvan</name><affiliation><nlm:aff id="A32">Stanford University ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A34">Cancer Prevention Institute of California, 2201 Walnut Ave Suite 300, Fremont, CA 94538</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Cancer Prevention Institute of California, 2201 Walnut Ave Suite 300, Fremont</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A35">Stanford Cancer Institute and Department of Health Research and Policy, Stanford School of Medicine, Stanford, CA 94305</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford Cancer Institute and Department of Health Research and Policy, Stanford School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Hsieh, Chih Lin" sort="Hsieh, Chih Lin" uniqKey="Hsieh C" first="Chih-Lin" last="Hsieh">Chih-Lin Hsieh</name><affiliation><nlm:aff id="A32">Stanford University ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A36">Department of Urology and Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA 90089</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Urology and Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Catalona, William J" sort="Catalona, William J" uniqKey="Catalona W" first="William J." last="Catalona">William J. Catalona</name><affiliation wicri:level="2"><nlm:aff id="A37">Northwestern University ICPCG Group, Northwestern University Feinberg School of Medicine, Chicago, IL 60611</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Northwestern University ICPCG Group, Northwestern University Feinberg School of Medicine, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Zheng, S Lilly" sort="Zheng, S Lilly" uniqKey="Zheng S" first="S. Lilly" last="Zheng">S. Lilly Zheng</name><affiliation wicri:level="2"><nlm:aff id="A37">Northwestern University ICPCG Group, Northwestern University Feinberg School of Medicine, Chicago, IL 60611</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Northwestern University ICPCG Group, Northwestern University Feinberg School of Medicine, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Jin, Guangfu" sort="Jin, Guangfu" uniqKey="Jin G" first="Guangfu" last="Jin">Guangfu Jin</name><affiliation wicri:level="2"><nlm:aff id="A38">Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Lu, Lingyi" sort="Lu, Lingyi" uniqKey="Lu L" first="Lingyi" last="Lu">Lingyi Lu</name><affiliation wicri:level="2"><nlm:aff id="A38">Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Xu, Jianfeng" sort="Xu, Jianfeng" uniqKey="Xu J" first="Jianfeng" last="Xu">Jianfeng Xu</name><affiliation wicri:level="2"><nlm:aff id="A38">Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Camp, Nicola J" sort="Camp, Nicola J" uniqKey="Camp N" first="Nicola J." last="Camp">Nicola J. Camp</name><affiliation><nlm:aff id="A1">Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine</nlm:aff><wicri:noCountry code="subfield">University of Utah School of Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Cannon Albright, Lisa A" sort="Cannon Albright, Lisa A" uniqKey="Cannon Albright L" first="Lisa A." last="Cannon-Albright">Lisa A. Cannon-Albright</name><affiliation><nlm:aff id="A1">Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine</nlm:aff><wicri:noCountry code="subfield">University of Utah School of Medicine</wicri:noCountry></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24162621</idno><idno type="pmc">3945961</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945961</idno><idno type="RBID">PMC:3945961</idno><idno type="doi">10.1007/s00439-013-1384-2</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001F67</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F67</idno><idno type="wicri:Area/Pmc/Curation">001E21</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001E21</idno><idno type="wicri:Area/Pmc/Checkpoint">001C42</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001C42</idno><idno type="wicri:Area/Ncbi/Merge">001540</idno><idno type="wicri:Area/Ncbi/Curation">001540</idno><idno type="wicri:Area/Ncbi/Checkpoint">001540</idno><idno type="wicri:doubleKey">0340-6717:2013:Teerlink C:association:analysis:of</idno><idno type="wicri:Area/Main/Merge">004945</idno><idno type="wicri:Area/Main/Curation">004825</idno><idno type="wicri:Area/Main/Exploration">004825</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association analysis of 9,560 prostate cancer cases from the International Consortium of Prostate Cancer Genetics confirms the role of reported prostate-cancer associated SNPs for familial disease</title><author><name sortKey="Teerlink, Craig C" sort="Teerlink, Craig C" uniqKey="Teerlink C" first="Craig C." last="Teerlink">Craig C. Teerlink</name><affiliation><nlm:aff id="A1">Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine</nlm:aff><wicri:noCountry code="subfield">University of Utah School of Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Thibodeau, Stephen N" sort="Thibodeau, Stephen N" uniqKey="Thibodeau S" first="Stephen N." last="Thibodeau">Stephen N. Thibodeau</name><affiliation><nlm:aff id="A3">Mayo Clinic ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN 55905</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Lab Medicine and Pathology, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Mcdonnell, Shannon K" sort="Mcdonnell, Shannon K" uniqKey="Mcdonnell S" first="Shannon K." last="Mcdonnell">Shannon K. Mcdonnell</name><affiliation><nlm:aff id="A3">Mayo Clinic ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Schaid, Daniel J" sort="Schaid, Daniel J" uniqKey="Schaid D" first="Daniel J." last="Schaid">Daniel J. Schaid</name><affiliation><nlm:aff id="A3">Mayo Clinic ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Health Sciences Research, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Rinckleb, Antje" sort="Rinckleb, Antje" uniqKey="Rinckleb A" first="Antje" last="Rinckleb">Antje Rinckleb</name><affiliation><nlm:aff id="A6">University of Ulm ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="4"><nlm:aff id="A7">Department of Urology, University of Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Urology, University of Ulm</wicri:regionArea><placeName><settlement type="city">Ulm</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region></placeName><orgName type="university">Université d'Ulm</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A8">Institute for Human Genetics, University of Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Human Genetics, University of Ulm</wicri:regionArea><placeName><settlement type="city">Ulm</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Maier, Christiane" sort="Maier, Christiane" uniqKey="Maier C" first="Christiane" last="Maier">Christiane Maier</name><affiliation><nlm:aff id="A6">University of Ulm ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="4"><nlm:aff id="A7">Department of Urology, University of Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Urology, University of Ulm</wicri:regionArea><placeName><settlement type="city">Ulm</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region></placeName><orgName type="university">Université d'Ulm</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="A8">Institute for Human Genetics, University of Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Human Genetics, University of Ulm</wicri:regionArea><placeName><settlement type="city">Ulm</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Vogel, Walther" sort="Vogel, Walther" uniqKey="Vogel W" first="Walther" last="Vogel">Walther Vogel</name><affiliation><nlm:aff id="A6">University of Ulm ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="4"><nlm:aff id="A7">Department of Urology, University of Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Urology, University of Ulm</wicri:regionArea><placeName><settlement type="city">Ulm</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Cancel Tassin, Geraldine" sort="Cancel Tassin, Geraldine" uniqKey="Cancel Tassin G" first="Geraldine" last="Cancel-Tassin">Geraldine Cancel-Tassin</name><affiliation wicri:level="3"><nlm:aff id="A9">CeRePP ICPCG Group, Hopital Tenon, Assistance Publique-Hopitaux de Paris, Paris 75020, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CeRePP ICPCG Group, Hopital Tenon, Assistance Publique-Hopitaux de Paris, Paris 75020</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Egrot, Christophe" sort="Egrot, Christophe" uniqKey="Egrot C" first="Christophe" last="Egrot">Christophe Egrot</name><affiliation wicri:level="3"><nlm:aff id="A9">CeRePP ICPCG Group, Hopital Tenon, Assistance Publique-Hopitaux de Paris, Paris 75020, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CeRePP ICPCG Group, Hopital Tenon, Assistance Publique-Hopitaux de Paris, Paris 75020</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Cussenot, Olivier" sort="Cussenot, Olivier" uniqKey="Cussenot O" first="Olivier" last="Cussenot">Olivier Cussenot</name><affiliation wicri:level="3"><nlm:aff id="A9">CeRePP ICPCG Group, Hopital Tenon, Assistance Publique-Hopitaux de Paris, Paris 75020, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CeRePP ICPCG Group, Hopital Tenon, Assistance Publique-Hopitaux de Paris, Paris 75020</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Foulkes, William D" sort="Foulkes, William D" uniqKey="Foulkes W" first="William D." last="Foulkes">William D. Foulkes</name><affiliation><nlm:aff id="A10">ACTANE Consortium ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="4"><nlm:aff id="A11">Program in Cancer Genetics, McGill University, Montreal, Quebec H3T 1E2, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Program in Cancer Genetics, McGill University, Montreal, Quebec H3T 1E2</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="A10">ACTANE Consortium ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">Cancer Epidemiology Centre, Cancer Council Victoria, Carlton, VIC 3053, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Carlton, VIC 3053</wicri:regionArea><wicri:noRegion>VIC 3053</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A13">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, VIC 3010, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, VIC 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A10">ACTANE Consortium ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="4"><nlm:aff id="A13">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, VIC 3010, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, VIC 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="A10">ACTANE Consortium ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="A12">Cancer Epidemiology Centre, Cancer Council Victoria, Carlton, VIC 3053, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Carlton, VIC 3053</wicri:regionArea><wicri:noRegion>VIC 3053</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A13">Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, VIC 3010, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, VIC 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Eeles, Ros" sort="Eeles, Ros" uniqKey="Eeles R" first="Ros" last="Eeles">Ros Eeles</name><affiliation><nlm:aff id="A10">ACTANE Consortium ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Institute of Cancer Research, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation></author><author><name sortKey="Easton, Douglas" sort="Easton, Douglas" uniqKey="Easton D" first="Douglas" last="Easton">Douglas Easton</name><affiliation><nlm:aff id="A10">ACTANE Consortium ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN</wicri:regionArea><wicri:noRegion>Cambridge CB1 8RN</wicri:noRegion></affiliation></author><author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name><affiliation><nlm:aff id="A10">ACTANE Consortium ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Institute of Cancer Research, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation></author><author><name sortKey="Guy, Michelle" sort="Guy, Michelle" uniqKey="Guy M" first="Michelle" last="Guy">Michelle Guy</name><affiliation><nlm:aff id="A10">ACTANE Consortium ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Institute of Cancer Research, Sutton, Surrey SM2 5NG</wicri:regionArea><wicri:noRegion>Surrey SM2 5NG</wicri:noRegion></affiliation></author><author><name sortKey="Cooney, Kathleen A" sort="Cooney, Kathleen A" uniqKey="Cooney K" first="Kathleen A." last="Cooney">Kathleen A. Cooney</name><affiliation><nlm:aff id="A16">University of Michigan ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A17">Departments of Internal Medicine and Urology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Departments of Internal Medicine and Urology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Ray, Anna M" sort="Ray, Anna M" uniqKey="Ray A" first="Anna M." last="Ray">Anna M. Ray</name><affiliation><nlm:aff id="A16">University of Michigan ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A17">Departments of Internal Medicine and Urology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Departments of Internal Medicine and Urology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Zuhlke, Kimberly A" sort="Zuhlke, Kimberly A" uniqKey="Zuhlke K" first="Kimberly A." last="Zuhlke">Kimberly A. Zuhlke</name><affiliation><nlm:aff id="A16">University of Michigan ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A17">Departments of Internal Medicine and Urology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Departments of Internal Medicine and Urology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Lange, Ethan M" sort="Lange, Ethan M" uniqKey="Lange E" first="Ethan M." last="Lange">Ethan M. Lange</name><affiliation><nlm:aff id="A16">University of Michigan ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A18">Departments of Genetics and Biostatistics, University of North Carolina, Chapel Hill, NC 27599</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Departments of Genetics and Biostatistics, University of North Carolina, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M." last="Fitzgerald">Liesel M. Fitzgerald</name><affiliation><nlm:aff id="A19">FHCRC/NHGRI ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A20">Fred Hutchinson Cancer Research Center (FHCRC), Division of Public Health Sciences, Seattle, WA 98195</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center (FHCRC), Division of Public Health Sciences, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Stanford, Janet L" sort="Stanford, Janet L" uniqKey="Stanford J" first="Janet L." last="Stanford">Janet L. Stanford</name><affiliation><nlm:aff id="A19">FHCRC/NHGRI ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A20">Fred Hutchinson Cancer Research Center (FHCRC), Division of Public Health Sciences, Seattle, WA 98195</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center (FHCRC), Division of Public Health Sciences, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Ostrander, Elaine A" sort="Ostrander, Elaine A" uniqKey="Ostrander E" first="Elaine A." last="Ostrander">Elaine A. Ostrander</name><affiliation><nlm:aff id="A19">FHCRC/NHGRI ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A21">Cancer Genetics Branch, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Cancer Genetics Branch, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Wiley, Kathleen E" sort="Wiley, Kathleen E" uniqKey="Wiley K" first="Kathleen E." last="Wiley">Kathleen E. Wiley</name><affiliation wicri:level="2"><nlm:aff id="A22">Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD 21287</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Isaacs, Sarah D" sort="Isaacs, Sarah D" uniqKey="Isaacs S" first="Sarah D." last="Isaacs">Sarah D. Isaacs</name><affiliation wicri:level="2"><nlm:aff id="A22">Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD 21287</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Walsh, Patrick C" sort="Walsh, Patrick C" uniqKey="Walsh P" first="Patrick C." last="Walsh">Patrick C. Walsh</name><affiliation wicri:level="2"><nlm:aff id="A22">Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD 21287</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B." last="Isaacs">William B. Isaacs</name><affiliation wicri:level="2"><nlm:aff id="A22">Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD 21287</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Johns Hopkins University ICPCG Group, Department of Urology, Johns Hopkins Medical Institutions, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Wahlfors, Tiina" sort="Wahlfors, Tiina" uniqKey="Wahlfors T" first="Tiina" last="Wahlfors">Tiina Wahlfors</name><affiliation><nlm:aff id="A23">University of Tampere ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Institute of Biomedical Technology, University of Tampere, BioMediTech, and Centre for Laboratory Medicine, Tampere University Hospital, Tampere 33520, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Biomedical Technology, University of Tampere, BioMediTech, and Centre for Laboratory Medicine, Tampere University Hospital, Tampere 33520</wicri:regionArea><wicri:noRegion>Tampere 33520</wicri:noRegion></affiliation></author><author><name sortKey="Tammela, Teuvo" sort="Tammela, Teuvo" uniqKey="Tammela T" first="Teuvo" last="Tammela">Teuvo Tammela</name><affiliation><nlm:aff id="A23">University of Tampere ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="A25">Department of Urology, University of Tampere and Tampere University Hospital, Tampere 33520, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Urology, University of Tampere and Tampere University Hospital, Tampere 33520</wicri:regionArea><wicri:noRegion>Tampere 33520</wicri:noRegion></affiliation></author><author><name sortKey="Schleutker, Johanna" sort="Schleutker, Johanna" uniqKey="Schleutker J" first="Johanna" last="Schleutker">Johanna Schleutker</name><affiliation><nlm:aff id="A23">University of Tampere ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="4"><nlm:aff id="A26">Department of Medical Biochemistry and Genetics, University of Turku, Turku 20520, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medical Biochemistry and Genetics, University of Turku, Turku 20520</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region><settlement type="city">Turku</settlement></placeName><orgName type="university">Université de Turku</orgName></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation><nlm:aff id="A27">University of Umeå ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="3"><nlm:aff id="A28">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name><affiliation><nlm:aff id="A27">University of Umeå ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="3"><nlm:aff id="A28">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Emanuelsson, Monica" sort="Emanuelsson, Monica" uniqKey="Emanuelsson M" first="Monica" last="Emanuelsson">Monica Emanuelsson</name><affiliation><nlm:aff id="A27">University of Umeå ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="A29">Oncologic Centre, Umeå University, Umeå 90187, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Oncologic Centre, Umeå University, Umeå 90187</wicri:regionArea><wicri:noRegion>Umeå 90187</wicri:noRegion></affiliation></author><author><name sortKey="Carpten, John" sort="Carpten, John" uniqKey="Carpten J" first="John" last="Carpten">John Carpten</name><affiliation wicri:level="2"><nlm:aff id="A30">Integrated Cancer Genomics Division, TGen, Phoenix, AZ 85004</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Integrated Cancer Genomics Division, TGen, Phoenix</wicri:cityArea></affiliation></author><author><name sortKey="Bailey Wilson, Joan" sort="Bailey Wilson, Joan" uniqKey="Bailey Wilson J" first="Joan" last="Bailey-Wilson">Joan Bailey-Wilson</name><affiliation wicri:level="2"><nlm:aff id="A31">Inherited Disease Research Branch, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Inherited Disease Research Branch, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name><affiliation><nlm:aff id="A32">Stanford University ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A33">Department of Health Research and Policy, Stanford School of Medicine, Stanford, CA 94305</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Health Research and Policy, Stanford School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Oakley Girvan, Ingrid" sort="Oakley Girvan, Ingrid" uniqKey="Oakley Girvan I" first="Ingrid" last="Oakley-Girvan">Ingrid Oakley-Girvan</name><affiliation><nlm:aff id="A32">Stanford University ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A34">Cancer Prevention Institute of California, 2201 Walnut Ave Suite 300, Fremont, CA 94538</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Cancer Prevention Institute of California, 2201 Walnut Ave Suite 300, Fremont</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A35">Stanford Cancer Institute and Department of Health Research and Policy, Stanford School of Medicine, Stanford, CA 94305</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford Cancer Institute and Department of Health Research and Policy, Stanford School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Hsieh, Chih Lin" sort="Hsieh, Chih Lin" uniqKey="Hsieh C" first="Chih-Lin" last="Hsieh">Chih-Lin Hsieh</name><affiliation><nlm:aff id="A32">Stanford University ICPCG Group</nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="A36">Department of Urology and Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA 90089</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Urology and Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Catalona, William J" sort="Catalona, William J" uniqKey="Catalona W" first="William J." last="Catalona">William J. Catalona</name><affiliation wicri:level="2"><nlm:aff id="A37">Northwestern University ICPCG Group, Northwestern University Feinberg School of Medicine, Chicago, IL 60611</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Northwestern University ICPCG Group, Northwestern University Feinberg School of Medicine, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Zheng, S Lilly" sort="Zheng, S Lilly" uniqKey="Zheng S" first="S. Lilly" last="Zheng">S. Lilly Zheng</name><affiliation wicri:level="2"><nlm:aff id="A37">Northwestern University ICPCG Group, Northwestern University Feinberg School of Medicine, Chicago, IL 60611</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Northwestern University ICPCG Group, Northwestern University Feinberg School of Medicine, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Jin, Guangfu" sort="Jin, Guangfu" uniqKey="Jin G" first="Guangfu" last="Jin">Guangfu Jin</name><affiliation wicri:level="2"><nlm:aff id="A38">Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Lu, Lingyi" sort="Lu, Lingyi" uniqKey="Lu L" first="Lingyi" last="Lu">Lingyi Lu</name><affiliation wicri:level="2"><nlm:aff id="A38">Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Xu, Jianfeng" sort="Xu, Jianfeng" uniqKey="Xu J" first="Jianfeng" last="Xu">Jianfeng Xu</name><affiliation wicri:level="2"><nlm:aff id="A38">Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Data Coordinating Center for the ICPCG and Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Camp, Nicola J" sort="Camp, Nicola J" uniqKey="Camp N" first="Nicola J." last="Camp">Nicola J. Camp</name><affiliation><nlm:aff id="A1">Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine</nlm:aff><wicri:noCountry code="subfield">University of Utah School of Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Cannon Albright, Lisa A" sort="Cannon Albright, Lisa A" uniqKey="Cannon Albright L" first="Lisa A." last="Cannon-Albright">Lisa A. Cannon-Albright</name><affiliation><nlm:aff id="A1">Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine</nlm:aff><wicri:noCountry code="subfield">University of Utah School of Medicine</wicri:noCountry></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City</wicri:cityArea></affiliation></author></analytic><series><title level="j">Human genetics</title><idno type="ISSN">0340-6717</idno><idno type="eISSN">1432-1203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Previous GWAS studies have reported significant associations between various common SNPs and prostate cancer risk using cases unselected for family history. How these variants influence risk in familial prostate cancer is not well studied. Here, we analyzed 25 previously reported SNPs across 14 loci from prior prostate cancer GWAS. The International Consortium for Prostate Cancer Genetics (ICPCG) previously validated some of these using a family-based association method (FBAT). However, this approach suffered reduced power due to the conditional statistics implemented in FBAT. Here, we use a case-control design with an empirical analysis strategy to analyze the ICPCG resource for association between these 25 SNPs and familial prostate cancer risk. Fourteen sites contributed 12,506 samples (9,560 prostate cancer cases, 3,368 with aggressive disease, and 2,946 controls from 2,283 pedigrees). We performed association analysis with Genie software which accounts for relationships. We analyzed all familial prostate cancer cases and the subset of aggressive cases. For the familial prostate cancer phenotype, 20 of the 25 SNPs were at least nominally associated with prostate cancer and 16 remained significant after multiple testing correction (p≤1E<sup>−3</sup>) occurring on chromosomal bands 6q25, 7p15, 8q24, 10q11, 11q13, 17q12, 17q24, and Xp11. For aggressive disease, 16 of the SNPs had at least nominal evidence and 8 were statistically significant including 2p15. The results indicate that the majority of common, low-risk alleles identified in GWAS studies for all prostate cancer also contribute risk for familial prostate cancer, and that some may be contribute risk to aggressive disease.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Finlande</li><li>France</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Arizona</li><li>Bade-Wurtemberg</li><li>Californie</li><li>Caroline du Nord</li><li>District de Tübingen</li><li>Finlande occidentale</li><li>Illinois</li><li>Maryland</li><li>Michigan</li><li>Minnesota</li><li>Québec</li><li>Svealand</li><li>Utah</li><li>Victoria (État)</li><li>Washington (État)</li><li>Île-de-France</li></region><settlement><li>Melbourne</li><li>Montréal</li><li>Stockholm</li><li>Turku</li><li>Ulm</li></settlement><orgName><li>Université McGill</li><li>Université d'Ulm</li><li>Université de Melbourne</li><li>Université de Turku</li></orgName></list><tree><noCountry><name sortKey="Camp, Nicola J" sort="Camp, Nicola J" uniqKey="Camp N" first="Nicola J." last="Camp">Nicola J. Camp</name><name sortKey="Teerlink, Craig C" sort="Teerlink, Craig C" uniqKey="Teerlink C" first="Craig C." last="Teerlink">Craig C. Teerlink</name></noCountry><country name="États-Unis"><region name="Minnesota"><name sortKey="Thibodeau, Stephen N" sort="Thibodeau, Stephen N" uniqKey="Thibodeau S" first="Stephen N." last="Thibodeau">Stephen N. Thibodeau</name></region><name sortKey="Bailey Wilson, Joan" sort="Bailey Wilson, Joan" uniqKey="Bailey Wilson J" first="Joan" last="Bailey-Wilson">Joan Bailey-Wilson</name><name sortKey="Cannon Albright, Lisa A" sort="Cannon Albright, Lisa A" uniqKey="Cannon Albright L" first="Lisa A." last="Cannon-Albright">Lisa A. Cannon-Albright</name><name sortKey="Carpten, John" sort="Carpten, John" uniqKey="Carpten J" first="John" last="Carpten">John Carpten</name><name sortKey="Catalona, William J" sort="Catalona, William J" uniqKey="Catalona W" first="William J." last="Catalona">William J. Catalona</name><name sortKey="Cooney, Kathleen A" sort="Cooney, Kathleen A" uniqKey="Cooney K" first="Kathleen A." last="Cooney">Kathleen A. Cooney</name><name sortKey="Fitzgerald, Liesel M" sort="Fitzgerald, Liesel M" uniqKey="Fitzgerald L" first="Liesel M." last="Fitzgerald">Liesel M. Fitzgerald</name><name sortKey="Hsieh, Chih Lin" sort="Hsieh, Chih Lin" uniqKey="Hsieh C" first="Chih-Lin" last="Hsieh">Chih-Lin Hsieh</name><name sortKey="Isaacs, Sarah D" sort="Isaacs, Sarah D" uniqKey="Isaacs S" first="Sarah D." last="Isaacs">Sarah D. Isaacs</name><name sortKey="Isaacs, William B" sort="Isaacs, William B" uniqKey="Isaacs W" first="William B." last="Isaacs">William B. Isaacs</name><name sortKey="Jin, Guangfu" sort="Jin, Guangfu" uniqKey="Jin G" first="Guangfu" last="Jin">Guangfu Jin</name><name sortKey="Lange, Ethan M" sort="Lange, Ethan M" uniqKey="Lange E" first="Ethan M." last="Lange">Ethan M. Lange</name><name sortKey="Lu, Lingyi" sort="Lu, Lingyi" uniqKey="Lu L" first="Lingyi" last="Lu">Lingyi Lu</name><name sortKey="Mcdonnell, Shannon K" sort="Mcdonnell, Shannon K" uniqKey="Mcdonnell S" first="Shannon K." last="Mcdonnell">Shannon K. Mcdonnell</name><name sortKey="Oakley Girvan, Ingrid" sort="Oakley Girvan, Ingrid" uniqKey="Oakley Girvan I" first="Ingrid" last="Oakley-Girvan">Ingrid Oakley-Girvan</name><name sortKey="Oakley Girvan, Ingrid" sort="Oakley Girvan, Ingrid" uniqKey="Oakley Girvan I" first="Ingrid" last="Oakley-Girvan">Ingrid Oakley-Girvan</name><name sortKey="Ostrander, Elaine A" sort="Ostrander, Elaine A" uniqKey="Ostrander E" first="Elaine A." last="Ostrander">Elaine A. Ostrander</name><name sortKey="Ray, Anna M" sort="Ray, Anna M" uniqKey="Ray A" first="Anna M." last="Ray">Anna M. Ray</name><name sortKey="Schaid, Daniel J" sort="Schaid, Daniel J" uniqKey="Schaid D" first="Daniel J." last="Schaid">Daniel J. Schaid</name><name sortKey="Stanford, Janet L" sort="Stanford, Janet L" uniqKey="Stanford J" first="Janet L." last="Stanford">Janet L. Stanford</name><name sortKey="Walsh, Patrick C" sort="Walsh, Patrick C" uniqKey="Walsh P" first="Patrick C." last="Walsh">Patrick C. Walsh</name><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name><name sortKey="Wiley, Kathleen E" sort="Wiley, Kathleen E" uniqKey="Wiley K" first="Kathleen E." last="Wiley">Kathleen E. Wiley</name><name sortKey="Xu, Jianfeng" sort="Xu, Jianfeng" uniqKey="Xu J" first="Jianfeng" last="Xu">Jianfeng Xu</name><name sortKey="Zheng, S Lilly" sort="Zheng, S Lilly" uniqKey="Zheng S" first="S. Lilly" last="Zheng">S. Lilly Zheng</name><name sortKey="Zuhlke, Kimberly A" sort="Zuhlke, Kimberly A" uniqKey="Zuhlke K" first="Kimberly A." last="Zuhlke">Kimberly A. Zuhlke</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Rinckleb, Antje" sort="Rinckleb, Antje" uniqKey="Rinckleb A" first="Antje" last="Rinckleb">Antje Rinckleb</name></region><name sortKey="Maier, Christiane" sort="Maier, Christiane" uniqKey="Maier C" first="Christiane" last="Maier">Christiane Maier</name><name sortKey="Maier, Christiane" sort="Maier, Christiane" uniqKey="Maier C" first="Christiane" last="Maier">Christiane Maier</name><name sortKey="Rinckleb, Antje" sort="Rinckleb, Antje" uniqKey="Rinckleb A" first="Antje" last="Rinckleb">Antje Rinckleb</name><name sortKey="Vogel, Walther" sort="Vogel, Walther" uniqKey="Vogel W" first="Walther" last="Vogel">Walther Vogel</name></country><country name="France"><region name="Île-de-France"><name sortKey="Cancel Tassin, Geraldine" sort="Cancel Tassin, Geraldine" uniqKey="Cancel Tassin G" first="Geraldine" last="Cancel-Tassin">Geraldine Cancel-Tassin</name></region><name sortKey="Cussenot, Olivier" sort="Cussenot, Olivier" uniqKey="Cussenot O" first="Olivier" last="Cussenot">Olivier Cussenot</name><name sortKey="Egrot, Christophe" sort="Egrot, Christophe" uniqKey="Egrot C" first="Christophe" last="Egrot">Christophe Egrot</name></country><country name="Canada"><region name="Québec"><name sortKey="Foulkes, William D" sort="Foulkes, William D" uniqKey="Foulkes W" first="William D." last="Foulkes">William D. Foulkes</name></region></country><country name="Australie"><noRegion><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name></noRegion><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Eeles, Ros" sort="Eeles, Ros" uniqKey="Eeles R" first="Ros" last="Eeles">Ros Eeles</name></noRegion><name sortKey="Easton, Douglas" sort="Easton, Douglas" uniqKey="Easton D" first="Douglas" last="Easton">Douglas Easton</name><name sortKey="Guy, Michelle" sort="Guy, Michelle" uniqKey="Guy M" first="Michelle" last="Guy">Michelle Guy</name><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name></country><country name="Finlande"><noRegion><name sortKey="Wahlfors, Tiina" sort="Wahlfors, Tiina" uniqKey="Wahlfors T" first="Tiina" last="Wahlfors">Tiina Wahlfors</name></noRegion><name sortKey="Schleutker, Johanna" sort="Schleutker, Johanna" uniqKey="Schleutker J" first="Johanna" last="Schleutker">Johanna Schleutker</name><name sortKey="Tammela, Teuvo" sort="Tammela, Teuvo" uniqKey="Tammela T" first="Teuvo" last="Tammela">Teuvo Tammela</name></country><country name="Suède"><region name="Svealand"><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name></region><name sortKey="Emanuelsson, Monica" sort="Emanuelsson, Monica" uniqKey="Emanuelsson M" first="Monica" last="Emanuelsson">Monica Emanuelsson</name><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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